Activity Summary:
This activity will inform participants about the complex pathophysiology of NF1-PN and how an understanding of molecular pathways has led to the development of MEK inhibitors. The key published and ongoing clinical evidence on the utility of approved and emerging therapies for NF1-PN will be detailed to provide a strong foundation for clinical decision-making. An in-depth guide to recognize and diagnose patients with NF1-PN will also be discussed in this module to facilitate an accurate and timely diagnosis. Overall, this presentation will ensure that participants appreciate the need to recognize and treat NF1-PN among pediatric patients.

Activity Summary:
This activity will inform participants about the complex pathophysiology of NF1-PN and how an understanding of molecular pathways has led to the development of MEK inhibitors. The key published and ongoing clinical evidence on the utility of approved and emerging therapies for NF1-PN will be detailed to provide a strong foundation for clinical decision-making. An in-depth guide to recognize and diagnose patients with NF1-PN will also be discussed in this module to facilitate an accurate and timely diagnosis. Overall, this presentation will ensure that participants appreciate the need to recognize and treat NF1-PN among pediatric patients.

Activity Summary:

Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune liver disease that can progress to end-stage liver disease. Recent developments have led to important updates in the diagnosis and use of novel approaches in treatment for patients with PBC. This podcast will utilize a case-based discussion to address implications of risk stratification and practice-changing evidence for the long-term management among diverse patients with PBC. 

Activity Summary:
Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune liver disease that can progress to end-stage liver disease. Recent developments have led to important updates in the diagnosis and use of novel approaches in treatment for patients with PBC. This program will utilize case-based discussion to address implications of risk stratification and practice-changing evidence for the long-term management among diverse patients with PBC.

Activity Summary:
Gout remains the most common form of inflammatory arthritis in adults, yet it continues to be one of the most misunderstood and mismanaged chronic diseases in clinical practice. Despite clear treatment guidelines and a growing array of therapeutic options, a substantial proportion of patients experience persistent flares, disease progression, and comorbid complications due to clinical inertia, fragmented care, and limited provider awareness of emerging innovations. This podcast, presented by Dr. Robert Terkeltaub, seeks to modernize clinical approaches to gout, accelerate the adoption of new evidence and therapies, and ultimately improve the quality and consistency of care for a patient population long underserved by existing education.

Activity Summary:
This video Clinical Clip features a leading expert highlighting the latest advances in Acute Myeloid Leukemia(AML) treatments presented at the 66th ASH Annual Meeting and Exposition from December 7-10, 2024, in San Diego, CA.

Activity Summary:
Gout remains the most common form of inflammatory arthritis in adults, yet it continues to be one of the most misunderstood and mismanaged chronic diseases in clinical practice. Despite clear treatment guidelines and a growing array of therapeutic options, a substantial proportion of patients experience persistent flares, disease progression, and comorbid complications due to clinical inertia, fragmented care, and limited provider awareness of emerging innovations. This Lecture Library, presented by Dr. Robert Terkeltaub, seeks to modernize clinical approaches to gout, accelerate the adoption of new evidence and therapies, and ultimately improve the quality and consistency of care for a patient population long underserved by existing education.

Activity Summary:
To reinforce key learnings and support practical implementation of the HCM clips highlighting data presented at the 2025 ESC Congress, this library provides supplemental resources available for download or online reference. These materials are designed to provide clinicians with quick-reference tools, visual summaries, and ready-to-use content that can be revisited after the highlights video and/or podcast and can also be shared within clinical teams.

Summary of Downloadable Resources for this Activity Include:

• Clinical Snippet Highlights
  • One-page summaries of key ESC 2025 data designed to provide actionable takeaways in a quick-reference format for everyday clinical use.
• Downloadable Slides
  • A PDF version of the presentation slides, including data visuals, algorithms, and speaker insights. This is provide to provide learners a structured overview of each topic which is ideal for review, team meetings or local education.
• Expert Commentary (Transcript)
  • A PDF version of the transcripts of the podcast for learners who prefer to read along or save for future reference.

This activity is not designated for continuing education credit. This is in no way a reflection of the integrity or quality of the content.

Activity Summary:
Conversations in HIV: Patient Voices Guiding Physician Choices in HIV Management is a roundtable, case-based format that incorporates the patient voice to discuss treatment concerns, translatability of recent study results to clinical practice, and management strategies to improve patient outcomes. Agenda topic examples: age and complex medical comorbidities, coinfection, social determinants of health, adherence/resistance, and transgender/HIV challenges.

Activity Summary:
Conversations in HIV: Patient Voices Guiding Physician Choices in HIV Management is a roundtable, case-based format that incorporates the patient voice to discuss treatment concerns, translatability of recent study results to clinical practice, and management strategies to improve patient outcomes. Agenda topic examples: age and complex medical comorbidities, coinfection, social determinants of health, adherence/resistance, and transgender/HIV challenges.

Activity Summary:
Clinicians usually face complex scenarios during screening for, diagnosing, and managing patients with ILD-PH. During this podcast epiosde, Dr. Jean Elwing discusses three case studies to illustrate the best-practice approaches to guide decisions and management:

• Case 1: A 68-year-old male with combined pulmonary fibrosis and emphysema
• Case 2: A 57-year-old male with IPF who presents with mild PH
• Case 3: A 35-year-old female with possible scleroderma overlap associated with ILD