Activity Summary:
To reinforce key learnings and support practical implementation of the HCM clips highlighting data presented at the 2025 ESC Congress, this library provides supplemental resources available for download or online reference. These materials are designed to provide clinicians with quick-reference tools, visual summaries, and ready-to-use content that can be revisited after the highlights video and/or podcast and can also be shared within clinical teams.

Summary of Downloadable Resources for this Activity Include:

• Clinical Snippet Highlights
  • One-page summaries of key ESC 2025 data designed to provide actionable takeaways in a quick-reference format for everyday clinical use.
• Downloadable Slides
  • A PDF version of the presentation slides, including data visuals, algorithms, and speaker insights. This is provide to provide learners a structured overview of each topic which is ideal for review, team meetings or local education.
• Expert Commentary (Transcript)
  • A PDF version of the transcripts of the podcast for learners who prefer to read along or save for future reference.

This activity is not designated for continuing education credit. This is in no way a reflection of the integrity or quality of the content.

Activity Summary:
Conversations in HIV: Patient Voices Guiding Physician Choices in HIV Management is a roundtable, case-based format that incorporates the patient voice to discuss treatment concerns, translatability of recent study results to clinical practice, & management strategies to improve patient outcomes. Agenda topic examples: age & complex medical comorbidities, coinfection, social determinants of health, adherence/resistance, & transgender/HIV challenges.

Activity Summary:
Conversations in HIV: Patient Voices Guiding Physician Choices in HIV Management is a roundtable, case-based format that incorporates the patient voice to discuss treatment concerns, translatability of recent study results to clinical practice, & management strategies to improve patient outcomes. Agenda topic examples: age & complex medical comorbidities, coinfection, social determinants of health, adherence/resistance, & transgender/HIV challenges.

Activity Summary:
Clinicians usually face complex scenarios during screening for, diagnosing, and managing patients with ILD-PH. During this podcast epiosde, Dr. Jean Elwing discusses three case studies to illustrate the best-practice approaches to guide decisions and management:

• Case 1: A 68-year-old male with combined pulmonary fibrosis and emphysema
• Case 2: A 57-year-old male with IPF who presents with mild PH
• Case 3: A 35-year-old female with possible scleroderma overlap associated with ILD

Activity Summary:
During this educational podcast, Dr. Martin Maron highlights the latest advances in HCM presented at the ESC Congress 2025 in Madrid, Spain, August 29-September 1, 2025.

Noteworthy presentations, posters, and abstracts are presented from the conference that are of high clinical significance to improve HCM.

Activity Summary:
Hypertrophic Cardiomyopathy (HCM) remains a complex and frequently underdiagnosed cardiovascular condition that poses substantial challenges in recognition, risk stratification, and therapeutic management. During this Clinical Clip Video, Dr. Martin Maron highlights the latest advances in HCM presented at the ESC Congress 2025 in Madrid, Spain, August 29-September 1, 2025

Activity Summary:
Stay informed on the go with our expert-led podcast series dedicated to stroke prevention. Across seven short episodes, Dr.'s C. Michael Gibson and Manesh Patel explore the shifting landscape of antithrombotic therapy—especially the potential role of Factor XIa inhibitors. From trial data to clinical applications, this series distills what you need to know to enhance patient care and reduce stroke risk.

Activity Summary:
The introduction of kinase inhibitors has significantly impacted the treatment landscape of plexiform neurofibromas (PN) associated with neurofibromatosis type 1 (NF1). In this Clinical Clip activity from the 2025 Annual Oncology Meeting, noteworthy data in NF1-PN has been summarized and evaluated by Dr. Amy Armstrong. This activity is AMA/ABS/ANCC/ACPE accredited for one-year.

Activity Summary:
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder marked by reduced platelet counts, purpura, and bleeding episodes driven by antiplatelet autoantibodies. Diagnosis remains one of exclusion, requiring careful differentiation from other causes of thrombocytopenia. Advances in pediatric ITP treatment are ushering in an era of precision medicine, integrating novel immunomodulatory therapies and personalized treatment approaches to optimize patient care. Recent research has introduced targeted pharmacological agents that address immune dysregulation, refining treatment protocols to align with individual patient profiles. The evolving landscape of pediatric ITP care calls for a comprehensive, evidence-driven approach, combining established therapies with innovative strategies to enhance efficacy and long-term disease management.

In this lecture library, Dr. Cindy Neunert, provides expert insights into emerging data on ITP pathophysiology, diagnosis, and treatment, equipping healthcare providers with the knowledge to translate new research into clinical practice and improve pediatric patient care.

Activity Summary:
Stroke prevention continues to challenge clinicians, especially when balancing effective anticoagulation with the risks of bleeding. During this video series, Dr.'s C. Michael Gibson and Manesh Patel provide rapid updates on the latest science shaping stroke prevention. Each 10–15-minute episode delivers digestible insights on topics such as emerging anticoagulation strategies, residual stroke risk, and clinical trial takeaways. This series is perfect for time-pressed healthcare professionals as it offers actionable knowledge designed to support evidence-based decision-making.

Activity Summary:
Myasthenia Gravis (MG) has had significant advances, however critical gaps persist in optimizing care. Challenges include variability in diagnostic accuracy, particularly in seronegative cases, and a limited adoption of newer, more sensitive testing modalities. Additionally, the evolving treatment landscape—with emerging therapies such as complement inhibitors and FcRn antagonists—highlights the need for clinicians to stay informed about the latest evidence and integrate these options into personalized care strategies. Addressing these gaps is crucial to improving patient care, enhancing quality of life, and reducing the burden of long-term side effects associated with traditional treatments.

This special edition podcast series with Dr. Nicholas Silvestri enables healthcare providers to engage with evidence-based insights and practical guidance on MG management at their convenience. The podcast format is ideal for professionals to access while commuting, during breaks, or between patient appointments, providing targeted learning without disrupting their workflow.

Activity Summary:
Pulmonary hypertension among patients with interstitial lung diseases (ILD-PH) is associated with increased morbidity, mortality, and healthcare burden and is currently under-recognized in clinical practice. To improve outcomes, early detection, timely diagnosis, and treatment of this complication among patients with ILD is an urgent priority.

Throughout this case-based presentation, Dr. Jean Elwing informs and guides on the latest insights to screen for, detect, accurately diagnose, and assess the severity of ILD-PH. Dr. Elwing also includes a discussion on identifying the right time and patient for a right heart catheterization, as it represents a complex and confounding decision in current clinical practice.

Activity Summary:
Clinicians often encounter patients having complex clinical scenarios when managing PAH where diverse and dynamic diagnostic and therapeutic issues interact. In this advanced case-based presentation, Dr. Ronald Oudiz discusses complex clinical case scenarios to improve knowledge on the diagnosis and management of pulmonary arterial hypertension and its application in practice.

• Case 1: Newly Diagnosed PAH with Coexisting Connective Tissue Disease
• Case 2: PAH with Refractory Right Heart Failure (RHF) and Multiorgan Dysfunction
• Case 3: Methamphetamine-Associated PAH with Severe PH and Psychiatric Comorbidities
• Case 4: Pediatric PAH in a Child with Congenital Heart Disease and Postoperative Complications

Activity Summary:
Advances in HIV research often unfold rapidly. In order to deliver state-of-the-art care, healthcare providers who manage this patient population must stay abreast of data emerging from the major conferences.

These educational Clinical Clip podcasts will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with "what you need to know" videos from data presented at IAS 2025.

Activity Summary:
Advances in HIV research often unfold rapidly. In order to deliver state-of-the-art care, healthcare providers who manage this patient population must stay abreast of data emerging from the major conferences.

These educational Clinical Clips will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with "what you need to know" videos from data presented at IAS 2025.

Activity Summary:
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder marked by reduced platelet counts, purpura, and bleeding episodes driven by antiplatelet autoantibodies. Diagnosis remains one of exclusion, requiring careful differentiation from other causes of thrombocytopenia. Advances in pediatric ITP treatment are ushering in an era of precision medicine, integrating novel immunomodulatory therapies and personalized treatment approaches to optimize patient care. Recent research has introduced targeted pharmacological agents that address immune dysregulation, refining treatment protocols to align with individual patient profiles. The evolving landscape of pediatric ITP care calls for a comprehensive, evidence-driven approach, combining established therapies with innovative strategies to enhance efficacy and long-term disease management.

In this podcast, Dr. Cindy Neunert, provides expert insights into emerging data on ITP pathophysiology, diagnosis, and treatment, equipping healthcare providers with the knowledge to translate new research into clinical practice and improve pediatric patient care.

Activity Summary:
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder marked by reduced platelet counts, purpura, and bleeding episodes driven by antiplatelet autoantibodies. Diagnosis remains one of exclusion, requiring careful differentiation from other causes of thrombocytopenia. Advances in pediatric ITP treatment are ushering in an era of precision medicine, integrating novel immunomodulatory therapies and personalized treatment approaches to optimize patient care. Recent research has introduced targeted pharmacological agents that address immune dysregulation, refining treatment protocols to align with individual patient profiles. The evolving landscape of pediatric ITP care calls for a comprehensive, evidence-driven approach, combining established therapies with innovative strategies to enhance efficacy and long-term disease management.

In this lecture library, Dr. Cindy Neunert, provides expert insights into emerging data on ITP pathophysiology, diagnosis, and treatment, equipping healthcare providers with the knowledge to translate new research into clinical practice and improve pediatric patient care.

Activity Summary:
The introduction of kinase inhibitors has significantly impacted the treatment landscape of plexiform neurofibromas (PN) associated with neurofibromatosis type 1 (NF1). In this podcast activity from the 2025 Annual Oncology Meeting, noteworthy data in NF1-PN has been summarized and evaluated by Dr. Amy Armstrong. This activity is AMA/ABS/ANCC/ACPE accredited for one-year.

Activity Summary:
During this educational podcast, Dr. Sonali Bose highlights the latest advances in COPD presented at the American Thoracic Society (ATS) International Conference in San Francisco, CA, May 17-21, 2025.

Noteworthy presentations, posters, and abstracts are presented from the conference that are of high clinical significance to improve COPD.

Activity Summary:
Chronic Obstructive Pulmonary Disease (COPD) remains a major global health burden with significant gaps in early diagnosis, personalized treatment, exacerbation prevention, and coordinated care. During this Clinical Clip video, Dr. Sonali Bose highlights the latest advances in COPD presented at the American Thoracic Society (ATS) International Conference in San Francisco, CA, May 17-21, 2025.

Activity Summary:
There continues to be significant progress in the treatment of primary biliary cholangitis (PBC) and these Clinical Clips from EASL 2025 have focused on the most impactful data presented at this conference. Dr. Nancy Reau will summarize key advances from EASL 2025 and describe their implications for clinical practice. 

Activity Summary:
There continues to be significant progress in the treatment of primary biliary cholangitis (PBC) and these Clinical Clips from EASL 2025 have focused on the most impactful data presented at this conference. Dr. Nancy Reau will summarize key advances from EASL 2025 and describe their implications for clinical practice. 

Activity Summary:
In this podcast titled "Emerging Evidence in Myasthenia Gravis: Key Updates from AAN 2025," Dr. Nicholas Silvestri provides healthcare professionals with an actionable update on recent advancements in MG; which features insights from groundbreaking research presented at AAN 2025.

Activity Summary:
In this Clinical Clip, Dr. Nicholas Silvestri provides a concise and clinically relevant summary of the most important emerging data presented at AAN 2025 that impact the management of generalized Myasthenia Gravis (gMG).

Topics covered include pivotal updates from recent clinical trials—such as MINT (inebilizumab), ADAPT NXT (efgartigimod), and MycarinG (rozanolixizumab)—highlighting the safety, efficacy, and practical implications of emerging therapies across diverse MG subtypes. The activity also explores trends in real-world treatment patterns, therapeutic inertia among neurologists, and new diagnostic approaches including advanced serologic testing and AI-supported electrophysiologic tools. With a focus on individualized care, this activity equips healthcare professionals with key insights to help integrate new therapies and diagnostic innovations into practice, ultimately supporting timely, targeted, and patient-centered management of MG.