Activity Summary:
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a poor prognosis. New and emerging agents may fulfill an unmet need for patients with TNBC. Rapidly evolving evidence in TNBC can present challenges in aligning practice with the latest clinical data and guideline recommendations. This virtual roundtable conversation is designed to provide learners with the opportunity to enhance clinical decision-making skills about the diagnosis and management of TNBC. Participants will review the latest clinical evidence and patient management approaches in TNBC to enhance patient-centered care. Faculty will also discuss new strategies and approaches to reduce breast cancer mortality and improve the health outcomes of racial/ethnic groups.

Activity Summary:
New frontiers for HIV therapy continue to be explored, as underscored by the clinical development and use of new agents, changing regimen strategies and development of long-acting novel agents. This expanding era of simplified and effective HIV therapy presents physicians with many new opportunities and challenges for providing care. To deliver state-of-the-art HIV prevention and care, healthcare providers must stay informed regularly of new clinical data and treatment recommendations in HIV.

This educational Quarterly Brief, covering HIV data from July through September of 2023, will discuss the most clinically relevant information on HIV Prevention, ART Studies: Treatment-Naive, ART Studies: Treatment-Experienced and 4. Cardiometabolic Considerations and Other HIV Studies.

Activity Summary:
Clinical Clips are accredited, on-demand video presentations that feature experts discussing recent clinical updates, hot topics and treatment options. This activity is designed to keep healthcare professionals on top of the most recent clinical findings.

This stand alone certified AMA/ANCC/ACPE enduring video will spotlight latest advances in the management of non-small cell lung cancer harboring EGFR Mutations through a 'what you need to know' video featuring a leading expert reporting from the 2023 ESMO Congress.

Activity Summary:
Patient Voices in HIV Management: A CE Podcast Series is an accredited continuing education series of podcasts as downloadable audio files (MP3). These podcasts will be recorded and made available throughout the year.

In this series of podcasts, the content faculty and one of their patients will discuss considerations and challenges in the prevention and treatment of HIV. Topics covered will include patient concerns, benefits and risks of antiretroviral therapy, and how patients have handled challenges in their HIV management.

Activity Summary:
Advances in HIV research often unfold rapidly. In order to deliver state-of-the-art care, healthcare providers who manage this patient population must stay abreast of data emerging from the major conferences.

These educational Clinical Clips will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of ‘what you need to know’ videos from data presented from the 2023 European AIDS Clinical Society Conference.

Activity Summary:
Advances in HIV research often unfold rapidly. In order to deliver state-of-the-art care, healthcare providers who manage this patient population must stay abreast of data emerging from the major conferences.

These educational Clinical Clips will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of ‘what you need to know’ videos from data presented from IDWeek 2023.

Activity Summary:
Despite dramatic advances in the development of treatments for pulmonary arterial hypertension (PAH), it remains a chronic life-threatening illness for which there is no cure. Advances in knowledge within the field are eagerly anticipated.

These educational Clinical Clips will spotlight important research into the basic science, diagnosis, treatment, and medical management of patients with PAH based on data presented at the American College of Chest Physicians (CHEST) Annual Meeting in Honolulu, HI, October 8-11, 2023.

Activity Summary:
This program will use a case-based format that incorporates the patient voice to discuss patient treatment concerns, translatability of recent study results to clinical practice, and management strategies to improve patient outcomes.

As our understanding of HIV and HIV therapy progress, so do our management approaches. Learning about concerns/barriers that patients with HIV face can lead to improved individualized outcomes as well as place the healthcare professional at the forefront of HIV care.

Activity Summary:
Conversations in Hematology/Oncology: Evolving Role of Bispecific Antibodies in B-cell Non-Hodgkin Lymphomas (B-NHL) is a roundtable discussion between leading experts to inform clinical practice about the rationale, safety, and efficacy of bispecific antibodies in B-NHL. The expert faculty will provide guidance on how to safely optimize therapy with bispecific antibodies to improve outcomes among patients. The activity will be supported by downloadable slides that have the key discussion/teaching points.

Activity Summary:
Clinical Viewpoints HLH/MAS includes a curriculum that highlights the very latest clinical data in hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Slides are developed and updated throughout the year by leading HLH/MAS expert physicians. All content is reviewed and approved by the Clinical Viewpoints HLH/MAS Planning Committee.

The current initial treatment for hemophagocytic lymphohistiocytosis (HLH) and/or macrophage activation syndrome (MAS) aims to suppress the excessive activation of the immune system and treat the cytokine storm. However, contemporary HLH and MAS management is an evolving science that builds off each advance in basic/clinical research and clinical experience. This case-based slide kit discusses current controversies in the management of secondary HLH, including MAS.

Activity Summary:
Current guidelines recommend initial oral combination therapy for patients with low- or intermediate-risk pulmonary arterial hypertension (PAH) and initial combination therapy including intravenous prostacyclin for high-risk patients. These strategies are based on using regular multiparameter mortality risk assessments and proactive therapy escalation to achieve and maintain a low-risk status. This approach has been shown to slow disease progression, optimize clinical outcomes, and improve survival. Furthermore, as interest towards personalized medicine grows, a comprehensive understanding of patient phenotypes through multiomics approaches, called deep phenotyping, is needed to provide further insights on pathogenesis, diagnosis, prognosis and therapeutic outcomes.

This AMA/ANCC/ACPE accredited, on-demand video addresses some key questions on combination therapy and deep phenotyping featuring a PAH expert answering important commonly asked questions.

Activity Summary:
What’s New Doc? is an accredited, on-demand video presentation featuring a pulmonary arterial hypertension (PAH) expert answering important questions asked about PAH. Two AMA/ANCC/ACPE videos will be launched throughout 2023.

Activity Summary:
Clinical Viewpoints PH-ILD includes a curriculum that highlights the very latest clinical data in pulmonary hypertension due to interstitial lung disease (PH-ILD). Slides are developed and updated throughout the year by leading pulmonology expert physicians. All content is reviewed and approved by the Clinical Viewpoints PH-ILD Planning Committee.

Pulmonary hypertension among patients with interstitial lung diseases is associated with increased morbidity, mortality, and healthcare burden. To improve outcomes, early detection and treatment of this complication among patients with ILD is an urgent priority. This slide kit will inform and guide on the latest recommendations and methodologies to screen for, detect, and accurately diagnose PH-ILD. The best-practice approaches to further treat and manage patients with PH-ILD will also be detailed. The case-based format will address knowledge and competence deficits among healthcare professionals regarding the diagnosis and treatment of PH-ILD. Overall, this module will narrow or close existing gaps in care to enable improved outcomes among patients with PH-ILD.

Activity Summary:
Simply Speaking PAH includes a curriculum that highlights the very latest clinical data in pulmonary arterial hypertension (PAH). Slides are developed and updated throughout the year by leading PAH expert physicians. All content is reviewed and approved by the Simply Speaking PAH Planning Committee.

Recent progress in pulmonary arterial hypertension (PAH) is based on new strategies for combination therapy and on the escalation of treatments to improve the significant morbidity and mortality associated with this disease. This case-based slide kit is designed to discuss the importance of monitoring patients to determine when and how to optimally alter their PAH therapy. Case 1 discusses a newly diagnosed PAH patient with a review of diagnosis, risk assessments, and initial combination therapy strategies. Case 2 discusses a high-risk PAH patient with a review of disease progression, risk assessment and treatment escalation options.

Activity Summary:
Advances in HIV research often unfold rapidly. In order to deliver state-of-the-art care, healthcare providers who manage this patient population must stay abreast of data emerging from the major conferences.

These educational Clinical Clips will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of ‘what you need to know’ videos from data presented from the 12th IAS Conference on HIV Science.

Activity Summary:
New frontiers for HIV therapy continue to be explored, as underscored by the clinical development and use of new agents, changing regimen strategies and development of long-acting novel agents. This expanding era of simplified and effective HIV therapy presents physicians with many new opportunities and challenges for providing care. To deliver state-of-the-art HIV prevention and care, healthcare providers must stay informed regularly of new clinical data and treatment recommendations in HIV.

This educational Quarterly Brief, covering HIV data from April through June of 2023, will discuss the most clinically relevant information ART Studies, Coinfections and Comorbidities, Women and HIV and Other Interesting HIV Research.

Activity Summary:
Simply Speaking PAH includes a curriculum that highlights the very latest clinical data in pulmonary arterial hypertension (PAH). Slides are developed and updated throughout the year by leading PAH expert physicians. All content is reviewed and approved by the Simply Speaking PAH Planning Committee.

Through patient cases, this slide kit provides learners with the opportunity to enhance clinical decision-making skills about the diagnosis and management of PAH. The module will take the learner through a complete virtual patient tour starting at the time of symptoms of PAH through diagnosis, evaluation, and how the disorder is managed. Case 1 will discuss how to manage the complications and precautions in a patient through pregnancy, labor and delivery, and the immediate postpartum period. Case 2 will discuss the common features of pediatric PAH with adult disease including the challenges that require unique approaches.

Activity Summary:
Quarterly Briefs on the Treatment for Early Lung Cancer: A Current Expert Analysis on Important Clinical Decisions is a video commentary discussing the latest study results, conference data and publications in targeted therapy and immunotherapy from the previous 3 months. The activity will be supported by downloadable slides that have the key discussion/teaching points.

Activity Summary:
Conversations and Updates in Gastric/GEJ Cancer is a roundtable discussion designed to inform and guide on the latest breakthroughs to improve patient outcomes.

This activity will involve discussion between key opinion leaders regarding the most recent advances in the second-line and subsequent treatment of gastric/GEJ cancer. The expert faculty will use case scenarios to enhance the learning experience and provide guidance on safely integrating recent progress into practice.

Activity Summary:
Conversations and Updates in Gastric/GEJ Cancer is a roundtable discussion designed to inform and guide on the latest breakthroughs to improve patient outcomes.

This activity will involve discussion between key opinion leaders regarding the most recent advances in the frontline treatment of gastric/GEJ cancer. The expert faculty will use case scenarios to enhance the learning experience and provide guidance on safely integrating recent progress into practice.

Activity Summary:
Conversations and Updates in Myelodysplastic Syndromes (MDS) is a roundtable discussion activity designed to inform and guide on the latest practice-changing insights to improve outcomes in both lower- and higher-risk MDS. The expert faculty presenters will discuss recent evidence and provide guidance on classifying, stratifying, and treating patients with MDS based on recent progress in the treatment continuum.

The activity is supported by downloadable slides that have the key discussion and teaching points.

Activity Summary:
Talking PAH is a webcast series that highlights the very latest clinical data in pulmonary arterial hypertension. Slides are developed and presented by leading PAH expert physicians and further reviewed and approved by the planning committee.

Over the past two decades, research has vastly improved the understanding of the pathophysiology, diagnosis, and treatment of pulmonary arterial hypertension (PAH). While no therapies have been approved to target new mechanisms of action in more than 15 years, multiple phase 2 and phase 3 clinical trials of novel therapies are underway. Further, management decisions regarding practical issues must also be addressed. Emerging research in accurate phenotyping of PH may also improve customization of therapies and prognostication as well as to increase the homogeneity of study cohorts in clinical trials. Improvements in the care of PAH patients depends on improving clinician awareness of the latest research into new diagnostic techniques, medications, and monitoring. This on-demand presentation is designed for the multi-disciplinary medical team and addresses the practical challenges of managing patients in the new era of PAH therapy.

Activity Summary:
Talking PAH is a webcast series that highlights the very latest clinical data in pulmonary arterial hypertension. Slides are developed and presented by leading PAH expert physicians and further reviewed and approved by the planning committee.

Pulmonary arterial hypertension (PAH) is a progressive and fatal lung disease of multifactorial etiology. Current therapies for treating pulmonary hypertension aim to overcome the imbalance between vasoactive and vasodilator mediators and restore the endothelial cell function. Extensive research efforts have led to the emergence of innovative therapeutic approaches in the area of PAH. This on-demand video presentation will focus on several important aspects of PAH management, including a discussion of the challenges of diagnosing and treating patients, clinical trial data on emerging therapeutics for the management of PAH, and a review of strategies to optimize outcomes for patients with PAH.

Activity Summary:
Despite dramatic advances in the development of treatments for pulmonary arterial hypertension (PAH), it remains a chronic life-threatening illness for which there is no cure. Advances in knowledge within the field are eagerly anticipated.

These educational Clinical Clips will spotlight important research into the basic science, diagnosis, treatment, and medical management of patients with PAH based on data presented at the American Thoracic Society (ATS) International Conference in Washington, DC, May 19-24, 2023.

Activity Summary:
Despite dramatic advances in the development of treatments for pulmonary arterial hypertension (PAH), it remains a chronic life-threatening illness for which there is no cure. Advances in knowledge within field are eagerly anticipated.

These educational Clinical Clips will spotlight important research into the basic science, diagnosis, treatment, and medical management of patients with PAH based on data presented at key pulmonology conferences in 2023 through “What You Need To Know in 5-minutes” video clips. Clinical Clips are accredited for AMA/ANCC/ACPE accreditation with the completion of an evaluation and post-test.

Activity Summary:
Talking PAH is a webcast series that highlights the very latest clinical data in pulmonary arterial hypertension. Slides are developed and presented by leading PAH expert physicians and further reviewed and approved by the planning committee.

Pulmonary Hypertension (PH) is currently divided into World Health Organization (WHO) groups based on the perceived etiology of the vascular insult: PAH (Group 1), PH due to left heart disease (Group 2), PH due to lung disease and/or hypoxia (Group 3), PH due to pulmonary artery obstructions (Group 4), and PH due to unclear and/or multifactorial mechanisms (Group 5). Accordingly, therapeutic interventions to address PH differ significantly between groups. However, this classification is less than perfect as there is not only considerable heterogeneity within each group but also overlap between groups. Emerging evidence on phenotyping PH may assist to address these limitations. This on-demand video presentation presents the latest research in diagnosing and managing Groups 2-5 in patients, including a discussion of the distinctions in specific groups – CTEPH, PH-ILD, PH-COPD.

Activity Summary:
Conversations in High-Risk NMIBC is a roundtable discussion featuring a urologist and two oncologists. The expert faculty will detail and reflect on recent advances in the treatment and management of high-risk NMIBC.

The activity will be supported by downloadable slides that have the key discussion and teaching points.

Activity Summary:
New frontiers for HIV therapy continue to be explored, as underscored by the clinical development and use of new agents, changing regimen strategies and development of long-acting novel agents. This expanding era of simplified and effective HIV therapy presents physicians with many new opportunities and challenges for providing care. To deliver state-of-the-art HIV prevention and care, healthcare providers must stay informed regularly of new clinical data and treatment recommendations in HIV.

This educational Quarterly Brief, covering HIV data from January through March of 2023, will discuss the most clinically relevant information regarding HIV/STI Prevention, General Health and ART, ART Switch Studies, and Investigational ART and Mpox.

Activity Summary:
We are pleased to have recently held the Optimal Management of HIV Disease & Hepatitis: Clinical Conference XXXI (OPMAN). The conference took place March 18-19, 2023, in Orlando, Florida with 15 leading clinicians and researchers presenting an array of topics covering HIV disease and liver disease. The presentations offered a unique distillation of clinically focused data tailored for practicing HIV and hepatitis healthcare professionals.

These accredited enduring video archives of OPMAN XXXI provide access to each day of the conference, including clinical presentations, interactive case discussions, and panel discussions addressing audience questions. CME/CE credit is provided separately by section so you can participate in only those sections of interest to you. We hope you enjoy this activity.

Activity Summary:
Simply Speaking PAH includes a curriculum that highlights the very latest clinical data in pulmonary arterial hypertension (PAH). Slides are developed and updated throughout the year by leading PAH expert physicians. All content is reviewed and approved by the Simply Speaking PAH Planning Committee.

PAH is characterized by increased pulmonary vascular resistance due to remodeling and occlusion of the pulmonary arterioles, resulting in right heart failure and death within 2-3 years of diagnosis if untreated. Despite advances in the diagnosis and treatment of PAH over the last two decades, the prognosis is still poor. Early recognition of disease, institution of effective PAH disease-specific therapy optimized for disease severity, and comprehensive care in specialized centers hold the promise of improving the outcome of patients. PAH is often misdiagnosed or unrecognized in clinical practice and delaying treatment options can worsen outcomes and survival. Diagnostic tests are needed to be done on anyone with unexplained dyspnea and suspected PAH. This on-demand presentation is designed using a case-based discussion on tools to improve the diagnosis of PAH and the importance of early referral.

Updated information is noted on the slide in the upper right hand corner. Please note that participants who have previously claimed credit for this activity should not claim duplicate credit based on the updates.