Activity Summary:
Patients with relapsed/refractory multiple myeloma (RRMM) are associated with poor survival outcomes and are in continual need of more effective therapies. Currently, a multitude of agents including monoclonal antibodies, proteosome inhibitors, immunomodulatory agents, bispecific antibodies, chimeric antigen receptor (CAR) T-cell therapy, and selinexor are available for patients with RRMM. More recently, the bispecific antibodies, teclistamab, elranatamab, and talquetamab have been approved for the treatment of RRMM and are also under investigation in combination with other agents and in different settings of MM.

In this podcast series, leading experts summarize the rationale/mechanism of action and clinical evidence on approved and emerging bispecific antibody therapy in RRMM and aid participants in using these agents safely by using clinical vignettes. The activity also provides guidance on early recognition of key adverse events and strategies to manage them, to ultimately improve outcomes for patients with RRMM.

Activity Summary:
Patients with relapsed/refractory multiple myeloma (RRMM) are associated with poor survival outcomes and are in continual need of more effective therapies. Currently, a multitude of agents including monoclonal antibodies, proteosome inhibitors, immunomodulatory agents, bispecific antibodies, chimeric antigen receptor (CAR) T-cell therapy, and selinexor are available for patients with RRMM. More recently, the bispecific antibodies, teclistamab, elranatamab, and talquetamab have been approved for the treatment of RRMM and are also under investigation in combination with other agents and in different settings of MM.

In this roundtable discussion, leading experts summarize the rationale/mechanism of action and clinical evidence on approved and emerging bispecific antibody therapy in RRMM and aid participants in using these agents safely by using clinical vignettes. The activity also provides guidance on early recognition of key adverse events and strategies to manage them, to ultimately improve outcomes for patients with RRMM.

Activity Summary:
The most recent guidelines recommend germline and/or somatic homologous recombination repair (HRR) gene panel testing to identify patients with metastatic prostate cancer that can benefit from poly-ADP ribose polymerase (PARP) inhibitors. However, HRR gene mutation (HRRm) testing rates are low and as a result, many patients with metastatic prostate cancer are unable to avail of these new therapies that have the potential to improve survival outcomes. This has been attributed to limited awareness about testing, inadequate sample, challenges with reimbursement, lack of patient counseling, and costs. Improving clinician and allied healthcare professional familiarity with HRRm testing guidelines and implementation recommendations, is therefore of utmost importance.

In this live webcast, Drs. Andrew Armstrong and Tanya Dorff will use a discussion and case-based format to clarify the rationale for HRRm testing in metastatic prostate cancer and ensure better integration of the latest guidelines for testing by addressing barriers. The overall aim is to enable appropriate utilization of HRRm testing to ultimately improve outcomes among patients.

Activity Summary:
Conversations in Hematology/Oncology: Incorporating Key Updates in the Treatment of Follicular Lymphoma: A Discussion Following ASH 2023 on Assimilating Practice-Changing Breakthroughs is a podcast discussion between key opinion leaders to identify and integrate crucial advances in follicular lymphoma presented at the 2023 American Society of Hematology (ASH) annual conference.

Activity Summary:
Myelofibrosis (MF) is a complex myeloproliferative neoplasm (MPN) that profoundly impacts the lives of patients. Recent years have witnessed advancements in risk stratification, symptom management, and treatment options for patients with MF. Unmet needs include alleviation of limiting thrombocytopenia and anemia, halting disease progression to acute leukemia, and extending survival. This has stimulated the development and investigation of a number of new agents for MF treatment. This Conversations in MF podcast will discuss the most clinically relevant data and emerging strategies into practice to improve outcomes for patients with MF presented from the 2023 international meetings of the American Society of Clinical Oncology (ASCO), European Hematology Association (EHA) and Society of Hematologic Oncology (SOHO).

Activity Summary:
Conversations in Hematology/Oncology: Incorporating Key Updates in the Treatment of Follicular Lymphoma: A Discussion Following ASH 2023 on Assimilating Practice-Changing Breakthroughs is a discussion between key opinion leaders to identify and integrate crucial advances in follicular lymphoma presented at the 2023 American Society of Hematology (ASH) annual conference.

Activity Summary:
Conversations and Cases in Oncology: Practice-Changing Updates in Systemic Treatment of Advanced Hepatocellular Carcinoma (HCC) is a roundtable discussion between leading experts to inform and guide on key updates. The expert faculty, Dr. Adam Burgoyne, Dr. Rachna Shroff and Dr. Mark Yarchoan, will discuss recent progress in different treatment settings of advanced HCC and provide insights into integrating new evidence into practice.

This activity will be supported by supplemental, downloadable slides as an educational resource.

Activity Summary:
Myelofibrosis (MF) is a complex myeloproliferative neoplasm (MPN) that profoundly impacts the lives of patients. Recent years have witnessed advancements in risk stratification, symptom management, and treatment options for patients with MF. Unmet needs include alleviation of limiting thrombocytopenia and anemia, halting disease progression to acute leukemia, and extending survival. This has stimulated the development and investigation of a number of new agents for MF treatment. This Conversations in MF will discuss the most clinically relevant data and emerging strategies into practice to improve outcomes for patients with MF presented from the 2023 international meetings of the American Society of Clinical Oncology (ASCO), European Hematology Association (EHA) and Society of Hematologic Oncology (SOHO).

The activity is supported by downloadable slides that have key discussion and teaching points.

Activity Summary:
Conversations in Advanced NSCLC: Rationale and Utility of TROP2 Antibody-Drug Conjugates Based on Updates from WCLC and ESMO is a podcast discussion between leading experts to inform and guide the safety and efficacy of trophoblast cell-surface antigen-directed antibody-drug conjugates (TROP2-directed ADCs) in different settings of non-small cell lung cancer (NSCLC) treatment that was reported at key conferences such as the World Conference on Lung Cancer (WCLC 2023) and European Society of Medical Oncology (ESMO 2023) annual conference. The expert faculty will also discuss insights into using agents upon availability to enable improved outcomes among distinct subsets of patients.

Activity Summary:
Immune thrombocytopenia (ITP) is an autoimmune disorder defined by a significantly reduced number of platelets in blood circulation. Due to low levels of platelets, ITP is associated with frequent bruising and bleeding. Current evidence suggests that low platelet counts in ITP are the result of multiple factors. Heterogeneity in patient population and characteristics make it challenging for the clinicians to choose appropriate therapeutic regimen. Clinicians must make decisions on the basis of the clinical presentation of each individual patient, ideally through a shared decision-making process that considers the patient’s values and preferences with respect to the anticipated outcomes of the chosen option.

During this accredited continuing education series of four (4) podcasts, Dr. James Bussel and Dr. Cindy Neunert discuss emerging evidence for management strategies for ITP, including utilization of patient reported outcomes and shared decision making to improve outcomes.

Activity Summary:
Conversations in Advanced NSCLC: Rationale and Utility of TROP2 Antibody-Drug Conjugates Based on Updates from WCLC and ESMO is a roundtable discussion between leading experts to inform and guide the safety and efficacy of trophoblast cell-surface antigen-directed antibody-drug conjugates (TROP2-directed ADCs) in different settings of non-small cell lung cancer (NSCLC) treatment that was reported at key conferences such as the World Conference on Lung Cancer (WCLC 2023) and European Society of Medical Oncology (ESMO 2023) annual conference. The expert faculty will also discuss insights into using agents upon availability to enable improved outcomes among distinct subsets of patients.

This activity is supported by downloadable slides that have the key discussion and teaching points.

Activity Summary:
Conversations in Acute Myeloid Leukemia: Novel Therapies Targeting the Immune System for Elderly/Unfit Patients is a podcast series between leading experts to inform and guide on breakthroughs and practice-changing updates. The expert faculty will discuss unmet needs in the treatment of elderly/unfit patients with AML and the role of novel therapies targeting the immune system in addressing them.

Activity Summary:
In this podcast series, Dr. Scott Canna and Dr. Alexei Grom discuss diverse mechanisms and clinical presentations in patients with suspected MAS, approaches for the timely diagnosis of MAS, and considerations for appropriate treatment and management strategies.

Activity Summary:
Conversations in Acute Myeloid Leukemia: Novel Therapies Targeting the Immune System for Elderly/Unfit Patients is a roundtable discussion between leading experts to inform and guide on breakthroughs and practice-changing updates. The expert faculty will discuss unmet needs in the treatment of elderly/unfit patients with AML and the role of novel therapies targeting the immune system in addressing them.

The activity is supported by downloadable slides that have the key discussion and teaching points.

Activity Summary:
Clinical Clips are accredited, on-demand video presentations that feature experts discussing recent clinical updates, hot topics and treatment options. This activity is designed to keep healthcare professionals on top of the most recent clinical findings.

This certified AMA/ABS/ANCC enduring video and podcast will spotlight latest advances in the treatment of ITP through a 'what you need to know' video featuring a leading expert reporting from the 2023 ASH Conference.

Activity Summary:
In this webcast archive, Dr. Scott Canna and Dr. Alexei Grom discuss diverse mechanisms and clinical presentations in patients with suspected MAS, approaches for the timely diagnosis of MAS, and considerations for appropriate treatment and management strategies.

Activity Summary:
Immune thrombocytopenia (ITP) is an autoimmune disorder defined by a significantly reduced number of platelets in blood circulation. Due to low levels of platelets, ITP is associated with frequent bruising and bleeding. Current evidence suggests that low platelet counts in ITP are the result of multiple factors. Heterogeneity in patient population and characteristics make it challenging for the clinicians to choose appropriate therapeutic regimen. Clinicians must make decisions on the basis of the clinical presentation of each individual patient, ideally through a shared decision-making process that considers the patient’s values and preferences with respect to the anticipated outcomes of the chosen option.

In this webcast archive, Dr. James Bussel and Dr. Cindy Neunert discuss emerging evidence for management strategies for ITP, including utilization of patient reported outcomes and shared decision making to improve outcomes.

Activity Summary:
During this podcast series, Guy Young, MD, and Angela Weyand, MD, will inform and guide on keeping up with recent progress and safely integrating it into clinical treatment paradigms of severe hemophilia A. Topics covered include recent practice-changing updates in replacement and non-replacement therapies in hemophilia A, case presentations to aid in selecting the most appropriate treatment for diverse patients with severe hemophilia A, novel non-replacement therapy and gene therapy as well as case scenarios to examine the utility of gene therapy.

Activity Summary:
During this webcast archive, Dr. Angela Weyand and Dr. Guy Young will discuss the latest practice-changing updates and breakthroughs in hemophilia A treatment paradigms, to ultimately improve outcomes among patients.

Please see the downloadable slides as a resource for key discussion and teaching points.

Activity Summary:
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a poor prognosis. New and emerging agents may fulfill an unmet need for patients with TNBC. Rapidly evolving evidence in TNBC can present challenges in aligning practice with the latest clinical data and guideline recommendations. This podcast series is designed to provide learners with the opportunity to enhance clinical decision-making skills about the diagnosis and management of TNBC. Participants will review the latest clinical evidence and patient management approaches in TNBC to enhance patient-centered care. Faculty will also discuss new strategies and approaches to reduce breast cancer mortality and improve the health outcomes of racial/ethnic groups.

Activity Summary:
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a poor prognosis. New and emerging agents may fulfill an unmet need for patients with TNBC. Rapidly evolving evidence in TNBC can present challenges in aligning practice with the latest clinical data and guideline recommendations. This virtual roundtable conversation is designed to provide learners with the opportunity to enhance clinical decision-making skills about the diagnosis and management of TNBC. Participants will review the latest clinical evidence and patient management approaches in TNBC to enhance patient-centered care. Faculty will also discuss new strategies and approaches to reduce breast cancer mortality and improve the health outcomes of racial/ethnic groups.

Activity Summary:
Clinical Clips are accredited, on-demand video presentations that feature experts discussing recent clinical updates, hot topics and treatment options. This activity is designed to keep healthcare professionals on top of the most recent clinical findings.

This stand alone certified AMA/ANCC/ACPE enduring video will spotlight latest advances in the management of non-small cell lung cancer harboring EGFR Mutations through a 'what you need to know' video featuring a leading expert reporting from the 2023 ESMO Congress.

Activity Summary:
Conversations in Hematology/Oncology: Evolving Role of Bispecific Antibodies in B-cell Non-Hodgkin Lymphomas (B-NHL) is a roundtable discussion between leading experts to inform clinical practice about the rationale, safety, and efficacy of bispecific antibodies in B-NHL. The expert faculty will provide guidance on how to safely optimize therapy with bispecific antibodies to improve outcomes among patients. The activity will be supported by downloadable slides that have the key discussion/teaching points.

Activity Summary:
Clinical Viewpoints HLH/MAS includes a curriculum that highlights the very latest clinical data in hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Slides are developed and updated throughout the year by leading HLH/MAS expert physicians. All content is reviewed and approved by the Clinical Viewpoints HLH/MAS Planning Committee.

The current initial treatment for hemophagocytic lymphohistiocytosis (HLH) and/or macrophage activation syndrome (MAS) aims to suppress the excessive activation of the immune system and treat the cytokine storm. However, contemporary HLH and MAS management is an evolving science that builds off each advance in basic/clinical research and clinical experience. This case-based slide kit discusses current controversies in the management of secondary HLH, including MAS.